Ga-67 for tumor


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Hodgkin's and non-Hodgkin's lymphoma
  • Assess response to therapy
  • Evaluate a mass persisting in CT after therapy
  • Differentiate viable tissue from fibrotic scar
  • Malignant Melanoma and Mets

  • Imaging too soon after chemotherapy
  • Ga-67 is excreted through breast milk, so patients should be notified that they should discontinue breast feeding after the study.

Questions asked in Patient History:

List the common questions asked when taking a patient history for this specific procedure.

Radiopharmaceutical information:
  • Radionuclide: Gallium Citrate
  • Radiopharmaceutical: Ga-67
  • Adult dosing: 8-10 mCi
  • Pediatric dosing: 75-100 microCuries/kg
  • Method of administration: Intravenously
  • Method of Localization: Ga-67 is an iron analog, it is transported in the blood by iron transport proteins (especially transferrin). Localizes in lysosomes
  • Physical Half-life: 78 hrs.

Patient Preparation:

  • Varies
  • May have bowel prep with laxatives and/or enema
  • May have patient eat low bulk diet before study

Side Effects:

Will the patient feel any different during or after the procedure?

Equipment Used:
Type of Camera or Probe: Large field of view; dual headed camera preferable
Collimator used: Medium Energy Parallel Hole

Acquisition Setup:

Photopeak(s): window around 93, 184, 296 keV

Window(s): 20%

Dynamic: View(s)
Number of Frames:

Statics: View(s)
Total Counts or Duration:

Whole body: View(s)
Matrix: 128 x 128 byte mode
Scan Speed: total = 30-40 minutes
Start/stop points: start - above head end - mid thigh

180 or 90 degree configuration :
Total Rotation: 180 or 360: 360 Degrees
Starting point:
Matrix: 128 x 128
Time/Azmuiths: 40 sec/stop
Number of Azmuiths: 60 stops/head



  1. Inject Ga-67 intravenously
  2. Delay images initially at 48-72 hours, and 5-10 days if needed
  3. Patient should be supine with arms above head.
  4. Planar imaging for a DUAL headed camera: simultaneously anterior and posterior whole body scanning mode requires 30-40 minutes.
  5. SPECT for a single headed camera: 500K spot images of anterior chest and equal time for posterior chest, anterior and posterior abdomen, pelvis, and head.

Normal Uptake and common varients:
  1. liver, spleen, salivary glands, bone marrow, lacrimal glands.
  2. large bowel clearance is variable
  3. Kidney is seen with intense uptake from 24-48 hours.

Abnormal Uptake and causes:

Four Months prior to presentation:

external image GaTl.GIF The top image is a Ga-67 which came up negative for non-hodgkins lymphoma. The bottom image is a Tl-201 image which shows increased activity in the left axillary region.

external image GaTl2.GIFThe top image, Ga-67 shows increased uptake in the left axillary region and left side of the neck. The Tl-201 image shows increased uptake biliaterally in the axillary region.

external image GaTl3.GIF
The top image, Ga-67, shows bilateral uptake in the axillary region and increased uptake on the left neck.

Panda Sign: Parotid glands visualized